INTERNATIONAL SYMPOSIUM ON DUPUYTREN DISEASE

This conference was organized by the International Dupuytren Society, hosted by the University Medical Center Groningen UMCG and supported by the Federation of European Societies for Surgery of the Hand FESSH and the International Federation of Societies for Surgery of the Hand IFSSH. The conference included academic research presentations and panel discussions regarding Dupuytren disease and related conditions. The goal of the conference has beenraising awareness regarding Dupuytren disease, sharing new concepts and ideas, and promoting cooperative efforts to work for a cure.

The symposium was a gathering of researchers and clinicians with a wide spectrum of interests: cell biology, genomics, surgery, pharmacotherapy, radiotherapy, biomechanics, therapy, as they relate to Dupuytren disease and related conditions. The conference was held at

22 / 23 May 2015, Groningen, The Netherlands

Accredited by EACCME for 12 CME points. Accredited by the Nederlandse Orthopaedische Vereniging (NOV)
and the Nederlandse Vereniging voor Plastische Chirurgie (NVPC) for 16 points.

The Groningen conference followed the symposium held in May 2010 in Miami, Florida (Conference History). Results of that conference have been published in Charles Eaton, Heinrich Seegenschmiedt, Ardheshir Bayat, Giulio Gabbiani, Paul Werker, and Wolfgang Wach (Eds.) “Dupuytren’s Disease and Related Hyperproliferative Disorders” Springer, 2012 ebook.

The proccedings of the Groningen conference have been published as book by Springer in 2016  proceedings.

Scientific Program

Note that the proceedings of this conference will be published by Springer as a book (printed and ebook) and will probably appear in June/July 2016.

Conference Program as PDF

Abstracts of presentations on Friday (including posters): abstracts_Friday

Abstracts of presentations on Saturday: abstracts_Saturday

Day 1  Friday, 22 May 2015

08:30	Paul Werker	Opening the conference
08:35	Jos Aartsen	Welcome from the CEO of UMCG
08:40	Wolfgang Wach & Charles Eaton	Welcome from the International Dupuytren Society & the Dupuytren Foundation	video
	Session 1	Epidemiology and Patients’ Views	B. Reichert, Z. Szabo
08:45	Zsolt Szabo	Lecture : Treatment of Dupuytren in different countries and the role of FESSH and IFSSH in promoting knowledge for hand surgeons	video
09:05	Joseph Dias	The epidemiology of surgical intervention for Dupuytren Contracture in England	video
09:11	Bert Reichert	Favorite Options of German Hand Surgeons in the Treatment of Dupuytren Disease	video
09:17	Philip Blazar	Trends in Dupuytren’s Treatment in the United States	video
09:23	Discussion
09:38	Wolfgang Wach	The Patient’s View and Needs – An International Survey: Dupuytren Disease	video
09:44	Hester Kan	Patients’ preferences for treatment for Dupuytren disease: a Discrete Choice Experiment
09:50	Discussion
	Session 2	Cellular and Extracellular Events	R. Bank, B. Hinz
10:30	David O’Gorman	Lecture : The extra­cellular matrix in Dupuytren disease	video
10:50	Marianna Kruithof‐de Julio	PDGFR-β targeted modified interferon gamma in Dupuytren disease
10:56	Marike van Beuge	Wnt pathway in Dupuytren disease, connecting pro-fibrotic signals	video
11:02	Ian Clark	Biomarkers of post-surgical outcome in Dupuytren disease	video
11:08	Jagdeep Nanchahal	Tumour necrosis factor (TNF) as a therapeutic target in Dupuytren disease	video
11:14	Discussion
11:30	David O’Gorman (chair)	Controversies 1: Pathogenesis of Dupuytren Disease: active or passive contracture?
11:32	Jagdeep Nanchahal	Active Contracture	video
11:37	Charles Eaton	Passive Contracture	video
	Session 3	Genetics and Associations	H. Hennies, R. Ophoff
13:00	Roel Ophoff	Lecture : Genetics in Dupuytren Disease
13:20	Michael Ng	A Large European Genome-wide Association Study Reveals Multiple New Genetic Susceptibility Variants for Dupuytren Disease	video
13:26	Kerstin Becker	Meta-analysis of genome-wide imputed GWAS identifies new significant loci in patients with Dupuytren´s disease
13:32	Juanjiangmeng Du	Identification and characterization of functional genetic variants in Dupuytren Disease
13:38	Discussion
13:53	Dieuwke Broekstra	A systematic review and meta-analysis on the association between Dupuytren disease and diabetes	video
13:59	Dieuwke Broekstra	The association between vibration and Dupuytren disease: a comparison between elderly field hockey players and controls	video
14:05	Discussion
14:15	Ilse Degreef (chair)	Controversies 2: The benefit of splinting for Dupuytren contracture
14:17	Adrian Chojnowski	Splinting confers no benefit	video
14:22	Wolfgang Wach	Splinting is beneficial	video
	Session 4	Collagenase Injection	S Coleman,S Wilbrand
15:15	Larry Hurst	Lecture : Collagenase Treatment – Journey from Bench to Current Advanced Clinical Use
15:35	Paul Werker	Dupuytren Disease in the thumb and first webspace and collagenase treatment	video
15:41	Jesper Nordenskjöld	Efficacy of using local anesthesia before collagenase injection in reducing overall pain experience in patients treated for Dupuytren’s contracture: A quasi-randomized study	video
15:47	Gary M. Pess	Effect of Delayed Finger Extension on the Efficacy and Safety of Collagenase Clostridium Histolyticum Treatment for Dupuytren Contracture	video
15:51	Massimo Corain	The use of a dynamic dorsal splint for Dupuytren Rehabilitation after collagenase	cancelled
15:57	Discussion
16:19	International Dupuytren Society	Dupuytren Award 2014 to Clayton Peimer
16:24	Clayton Peimer	Treatment with Collagenase Clostridium Histolyticum: Five-Year CORDLESS Data	video
16:30	Marie Badalamente	Prospective Multicenter, Multinational Study to Evaluate the Safety and Efficacy of Concurrent Collagenase Clostridium Histolyticum Injections to Treat Two Dupuytren Contractures in the Same Hand	video
16:36	Marie Badalamente	An Open-label, Controlled Phase 2a Study of the Safety and Efficacy of Injectable Collagenase Clostridium Histolyticum (CCH) in Patients with Adhesive Capsulitis (Frozen Shoulder)	video
16:42	David Warwick	Collagenase : what we may never know – a discussion paper	video
16:48	Discussion
17:04	Charles Eaton (chair)	Controversies 3: The best minimally invasive treatment for Dupuytren Disease:PNF or Collagenase?
17:06	Paul Werker	Percutaneous Needle Fasciotomy	video
17:11	David Warwick	Collagenase	video
Day 2  Saturday, 23 May 2015
	Session 5	Assessment / Percutaneous Needle Fasciotomy	U. Lanz, G. Pess
08:30	Joseph Dias	MCID for the Patient Evaluation Measure as a Patient Rated Outcome Measure for Dupuytren Contracture	video
08:36	Chao Zhou	Predictors of Satisfaction with Hand Function in Patients with Dupuytren Disease	video
08:42	Joseph Dias	URAMS as a PROM for Dupuytren Contracture Patients	video
08:48	Discussion
09:03	Gary Pess	Tips and Pearls for Percutaneous Needle Fasciotomy and Collagenase – A Ten Year Personal Experience	video
09:09	Margot Vlot	Percutaneous Needle Fasciotomy for secondary or higher recurrence in Dupuytren disease	video
09:15	Steven Hovius	Extensive Percutaneous Aponeurotomy and Lipofilling versus Limited Fasciectomy in Patients with Primary Dupuytren Contracture; a Randomized Controlled Trial	video
09:21	Discussion
09:37	Joseph Dias (chair)	Controversies 4: How to treat severe PIP contractures: minimally invasive or surgically?
09:41	Clayton Peimer	Minimally invasive methods
09:46	Caroline Leclercq	Surgical correction	video
	Session 6	Comparative Studies / Recurrence	C. Leclercq, D. Elliot
10:45	David Elliot	Lecture : Treatment of Dupuytren Disease – Where are we now?
11:05	Paul Binhammer	Steroid injection and needle aponeurotomy for Dupuytren disease: long-term follow-up of a randomized controlled trial	video
11:11	Eva-Maria Baur	Minimally invasive treatment of Dupuytren: Collagenase vs. PNF	video
11:17	Chao Zhou	Collagenase Clostridium Histolyticum versus Partial Fasciectomy for Dupuytren’s contracture: Early Outcomes From A Multicenter Propensity-Score Matched Study	video
11:23	Discussion
11:35	Jane C Messina	Actual Indications of Continuous Extension Technique (TEC) for Severe Dupuytren Disease	video
11:41	Atanu Biswas	Preliminary soft-tissue distraction versus checkrein ligament release after fasciectomy in the treatment of Dupuytren proximal interphalangeal joint contractures	video
11:47	Discussion
11:55	Rinze Zwanenburg	The Palmodigital Spiralling Sheath
12:01	Rosanne Lanting	Clusters in short term disease course in participants with primary Dupuytren Disease
12:07	Discussion
12:15	Ruud Selles	Recurrence after Treatment for Dupuytren Disease; A consensus-based definition	video
12:21	Caroline Leclercq	Recurrence after Dupuytren’s disease:the time factor
12:27	Ilse Degreef	Is Recurrence of Dupuytren Disease Prevented by Full-Thickness Grafting Surgery?	video
12:33	Discussion
	Session 7	Related disease & Other Treatments	R. Selles, R. Shaffer
13:50	Heinrich Seegenschmiedt	Lecture : Radiotherapy for Early Stage Dupuytren and Ledderhose Disease	video
14:10	Catherine Ball	A Systematic Review Of Non-Surgical Treatments for Early Dupuytren Disease	video
14:16	Gary Manley	The Patient’s View and Needs – An International Survey: Ledderhose Disease	video
14:22	Discussion
14:32	Gloria Sue	Use of Acellular Dermal Matrix in Dupuytren Disease	video
14:38	Ilse Degreef	In vivo RCT Tension versus compression on Dupuytren	video
14:44	Discussion
14:54	Mels van Driel	Lecture : Peyronie’s Disease Treatment: The State of the Art	video
	Symposia	Focus on Research	J. Dias
15:35	Joseph Dias	Introduction to the symposia	video
15:40	David O’Gorman	Basic Research: important prerequisites for future studies	D. O’Gorman video
	Ruud Bank	We need better methodologies for Dupuytren research	video
	Dominic Furniss	Requirements for genetic research and novel ways to attract funding	video
16:30	Maria Badalamente	Clinical Research: international collaboration to execute high powered clinical trials	M. Badalamente video
	Joseph Dias	Patient Rated Outcome Measures (PROMS)	video
	Charles Eaton	International Dupuytren Data Bank (IDDB)	video
	Steve Coleman	Clinical Research in Australia	video
17:20	Paul Werker	Closing remarks